Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism
Abstract Background The growth factor receptor bound protein underwater treasures sunken medallion 7 (Grb7) family of signalling adaptor proteins comprises Grb7, Grb10 and Grb14.Each can interact with the insulin receptor and other receptor tyrosine kinases, where Grb10 and Grb14 inhibit insulin receptor activity.In cell culture studies they mediat